Frequently Asked Questions

1. IS ONDROX PRICE REASONABLE?
2. WHAT ARE “FREE RADICALS?"
3. WHAT IS AN “ANTI-OXIDANT?"
4. WHO DEVELOPED ONDROX?
5. WAS THE ORIGINAL FORMULATION CHANGED?
6. WHAT IS THE RECOMMENDED USAGE OF ONDROX?
7. CAN I INCREASE THE USAGE?
8. CAN IT BE TAKEN WITH OTHER MEDICATION?
9. HOW IS IT DIFFERENT FROM OTHER ANTIOXIDANT?
10. WHAT IS MEANT BY “SYNERGY?"
11. WHAT IS “SUSTAINED RELEASE?"
12. CAN ONDROX REALLY PREVENT CANCER?
13. DOES ONDROX HAVE BAD SIDE EFFECTS?
14. WHY SOME STUDIES SHOW ANTIOXIDANTS ARE BAD?
15. HOW TO PROVE TECHNICALLY ONDROX WORKS.
16. WHAT ARE OTHER WAYS TO PROVE IT WORKS?
17. CAN ONDROX BE TAKEN BY CHILDREN?
18. WHO ARE THE OWNERS OF ONDROX?
19. ARE THERE RETAIL OUTLETS?
20. WHO IS THE MANUFACTURER OF ONDROX?

1. Is ONDROX price reasonable?

When ONDROX was first introduced, it was priced at $40.00 for the 30-day supply. Due to volume increase, the current retail price is only $29.95 for a 30-day supply of 60 tablets. It is higher than ordinary antioxidants or some multi-vitamins because:

• It contains not just a few but a total of 37 active ingredients (vitamins, minerals, antioxidants).
• It is a sustained release formulation, available round the clock to fight free radicals.
• It is a carefully selected combination of particular ingredients to provide synergistic benefits.
• It utilizes micro-encapsulation process to optimize synergistic value on certain ingredients.
• It includes other vitamins and minerals necessary to provide a complete daily requirement, eliminating the need for additional supplementation. If bought separately, the combined cost of all the ingredients in Ondrox will far exceed the unit cost of Ondrox itself.

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2. What is meant by “Free Radicals”?

Free radicals are atoms or groups of atoms with an odd (unpaired) number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these highly reactive radicals can start a chain reaction, like dominoes. Their chief danger comes from the damage they can do when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occurs. To prevent free radical damage the body has a defense system of antioxidants.

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3. What is meant by “Antioxidants”?

Antioxidants are molecules which can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged. Although there are several enzyme systems within the body that scavenge free radicals, the principal micronutrient (vitamin) antioxidants are vitamin E, A, beta-carotene (pro-Vitamin A), and vitamin C. Additionally, selenium, a trace metal that is required for proper function of one of the body's antioxidant enzyme systems, is sometimes included in this category. So are BHT and Propylgallate, The body cannot manufacture these micronutrients, especially as we age, so they must be supplied in the diet, or by supplements.

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4. Who developed Ondrox?

The core formulation was developed at M.D. Anderson Cancer Center by the Director of its Research Park at that time, Dr. Tom Slaga, and two scientists at the Biotics Research Corporation in Houston, Texas., Daryl Deluca, and William Sparks. The U.S. Patent for Ondrox was issued to these three inventors.

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5. Was the original formulation changed since its inception?

The formulation of Ondrox itself was changed since its introduction. Only 3 ingredients, which were added at the inception to the core formulation to provide a more complete daily requirement, were removed. One was iron because it is not desirable for some men, another was Omega 3 oil because it posed a stability question in the tablet, and the 3rd item that was deleted was the amino acid, L-Glutathione, because later studies showed a possible toxicity, and we did not want to take any chances with that. All the 37 other ingredients remain. The reformulation in 1994 of ONDROX was done in consultation with officials, including the Director of the M.D. Anderson Cancer Center’s Research Division, who also was one of the inventors of ONDROX, and who is a shareholder of LSI America Corporation. We have not changed the core formulation which was the subject of the trials conducted by M.D. Anderson Cancer Center, only the supplemental additional ingredients.

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6. What is the recommended usage of Ondrox?

Once in the morning and once in the evening after meals.

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7. Can I increase the usage?

If you are exposed to free radicals such as strenuous physical exertion, exposure to the sun or viruses, it is not harmful to consume more than 2 tablets a day. However, taking more than 4 pills a day would depend upon the individual’s condition.

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8. Can it be taken with other medication?

If you have a medical condition and believe that ONDROX could affect your condition in any way, you should consult your own physician. We cannot provide medical advice of any kind.

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9. How is it different from other antioxidants?

ONDROX contains the U.S. patented core formulation of more than one highly beneficial and synergistically acting antioxidants developed at M.D. Anderson Cancer Center, rated as the No. 1 cancer center in the U.S. by U.S. News & World Report. The formulation is comprised of ideal minimal amounts of several scientifically proven antioxidants that interact synergistically to give an optimum all day protection against cell damaging free radicals through sustained time release rather than just time release. Excesses of certain ingredients not only can be toxic, but can also specifically become “pro-oxidant” instead of “anti-oxidant”. ONDROX’ core formulation is calibrated with precise types, quality and minimal ideal quantity of different antioxidants to achieve its highest level of efficiency. In addition, ONDROX contains natural chemicals that also help to increase the effectiveness of cellular free radical defensive mechanism.

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10. What is meant by synergy of different ingredients contained in ONDROX ?

Animal trials conducted on the core formulation of ONDROX by M.D. Anderson Cancer Center, the leading independent non-profit top cancer research center, proved that combinations of specific antioxidants at relatively low doses gave a biologic response (preventing cancer in animals) much greater than individual antioxidants at very high doses. It means it is better than taking different antioxidants in massive quantities without consideration of good or bad effects of combining them.

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11. What is “sustained time release?”

“Time Release” usually describes the dissolution of the tablets uniformly but not gradually over a period of time. “Sustained Release” or “Sustained Time Release” means that dissolution of different ingredients in different proportions occur in a sustained manner, gradually, over time. This is important to create the synergy desired to achieve the optimum level of benefits, and above all, to sustain the level of bioavailability throughout the day.

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12. Can ONDROX really prevent cancer?

No antioxidant sold in America can claim that it will prevent cancer. By law such claims cannot be made without FDA approval, and tests on human beings are not practical or feasible. However, in the case of ONDROX, unlike most other antioxidant products, its core formulation was conceived and tested on animals by a foremost independent cancer research center. It was evolved and developed from extensive scientific tests conducted in a most precise manner by exposing test animals to carcinogens. The result is that ONDROX’ core formulation is proven by such tests in animals to be the most effective combination of antioxidants in not only preventing cancer, but also reducing cardio-vascular and immunological disorder on the test subjects. Furthermore, it was also shown to improve their longevity by up to 30%. In addition, various scientific studies indicate antioxidants are useful in fighting against free radicals, and free radicals cause cancers and other ailments in human beings. As such, ONDROX is the most promising of all such products to help build up antioxidants in the body. For these reasons and because the core formulation was the first to assert specified claims, the U.S. Patent Office granted the patent. Additionally, as a dietary supplement, ONDROX is permitted to be sold under the FDA guidelines. Above all, Ondrox formulation is the only antioxidant formulation endorsed by the National Foundation for Cancer Research.

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13. Does ONDROX have bad side effects?

ONDROX is being sold under the guidelines prescribed by FDA for the sale of over the counter nutritional supplement. As noted, ONDROX does not contain excessive amounts of any of its ingredients. It is designed to have no immediate or long term side effects, if taken as recommended. If an individual has a medical condition which is specifically counter-indicated for certain specific ingredients which may be present in ONDROX, the doctor supervising the treatment of that condition should be consulted before the individual takes on the program. As a general rule, any individual without a special medical problem can undertake the recommended ONDROX program without any concern for serious side effects. ONDROX does not contain any common allergen, or added additives.

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14. Why some studies show antioxidants are bad?

First, ONDROX’ core formulation contains only minimal quantities of each antioxidant which was tested to be the right optimal amount to produce the synergy that is most effective in controlling free radicals. No excessive quantity of any ingredient is included. For instance, Vitamin A content is only 2,000 I.U., not the 10,000 or more found to be harmful to certain individuals (e.g., expectant mothers). Beta Carotene (listed as Vitamin A) is only 10,000 I.U. which in the body will convert to Vitamin A only if needed. Second, most of the harmful effects found by researchers (the Finish study and the most recent National Cancer Institute study) were on those who are habitual heavy smokers who may have been prone to lung cancer to begin with. Thirdly, in the NCI study, they were given extremely high doses of Vitamin A (25,000 units!), in combination with Beta Carotene (3 milligrams), but without other antioxidants which are included in ONDROX’ core formulation; and in the Finish study, they were given below the least amount usually contained in supplements recommended for anti-free radical usage. Fourthly, such studies did show that for the non-smokers, even the excessive dosage of the one or two antioxidants tested did not produce any harmful effects. Lastly, most Americans do not consume enough fresh fruits and vegetables daily to obtain the minimal antioxidants recommended for the control of free radicals. For them, taking supplements will increase the availability of antioxidants in the body.

Furthermore, for one epidemiological study that is negative for antioxidants, there are many which are positive. For instance, in an epidemiological study in a small town near Beijing, China, the NCI found that antioxidant given to a control group resulted in significantly lower rate of cancer deaths. In addition to such studies, there are extensive favorable scientific reports on antioxidants studies, and free radicals and their relationship to cancer promotion, which indicate antioxidants can destroy free radicals that cause cancers and other ailments.

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15. How to prove technically ONDROX works?

There are conventional lab tests which could indicate if an individual is having a beneficial effect from taking ONDROX. These tests should be taken at the start of entering the ONDROX program and after six months into the program. Free radical damage can be measured in human in both the blood (lymphocytes) and the urine. Free radicals have been shown to increase the level of modified DNA bases. The level of modified DNA bases (especially 8-OH-dG) has been found to be higher in human cancer tissue. In addition, modified DNA bases increase as one grows older. The effects of antioxidants on the level of modified DNA bases can be determined in both blood and urine. In the blood the level of 8-OH-dG is measured in lymphocytes. In the urine the level of thymidine glycol is determined. There are several laboratories that routinely determine modified DNA bases in the blood and urine.

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16. What are other ways to prove it works?

As a nutritional supplement and as a part of the holistic approach to good health, ONDROX is potentially a contributor to the general well being. If the experiment is working for you, you should feel the effect in many ways. For instance, some individuals who suffer from immune related ailments, such as allergies, after one or two allergy seasons, have felt a reduced reliance on medications, after a year on the ONDROX program.

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17. Can ONDROX be taken by children?

Yes. It is recommended that minors who are age four and above could take the full level of recommended usage of one tablet twice daily. Younger children may want to take one-half of the recommended usage level.

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18. Who are the owners of ONDROX?

LifeScience Corporation is the original licensee of University of Texas M.D. Anderson Cancer Center on the vitamin formulation. LSI America Corporation acquired 80% controlling interest in LifeScience Corporation in May, 1995, so it is the parent company of LifeScience Corporation. University of Texas remains a 10% shareholder of LifeScience Corporation.

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19. Are there retail outlets?

ONDROX may be purchased directly from LSI America Corporation over the Internet www.ondrox.com or by phone, fax or mail. Certain stores in the U.S. are stocking the product. If you would like to purchase it from your pharmacy, please let them know that they can order it from LSI America. Contact: info@lsiamerica.com

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20. Who is the manufacturer?

Biotics Research Corporation, Houston, authorized by LSI America Corporation. Biotics is Federal Drug Administration approved “GMP” pharmaceutical manufacturing plant. “GMP” (“Good Manufacturing Plant”) is highest rated quality drug manufacturing facility.

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